C4orf51

Across TCGA patient cohorts, C4orf51 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf51-associated genes across cancer lineages are PI3K-p85, ERK2, and Annexin-1. Each is linked with C4orf51 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf51-to-partner and partner-to-C4orf51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p85 grouped by C4orf51-low versus C4orf51-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf51→partner) and Y-score (partner→C4orf51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p85 →	+0.337	+3.169	.003	.020	2	1
UCEC	ERK2 →	+0.383	+3.169	<.001	.020	1	1
UCEC	Annexin-1 →	+0.821	+3.169	.004	.020	1	1
UCEC	Caspase-7-cleavedD198 →	+1.105	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PI3K-p85 by C4orf51 expression — UCEC

Explore this box plot interactively →