C4orf51

Across TCGA pan-cancer cohorts, C4orf51 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated C4orf51 data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher C4orf51 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C4orf51 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LUAD show a favorable association.

ACC, SCLC, and LUSC are the cancer types where C4orf51 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.616	0.871	<.001	54	view →
SCLC	OS	Tertile	III,IV	0.395	0.690	.006	48	view →
LUSC	DFS	Median	II,III,IV	0.812	0.619	<.001	46	view →
LUAD	OS	Median	III,IV	0.630	0.378	<.001	46	view →
LGG	DFS	Tertile	All	0.640	0.785	<.001	33	view →
BRCA	OS	Median	All	0.906	0.940	.008	21	view →
MESO	OS	Median	All	0.430	0.643	.007	17	view →
KIRC	DFS	Tertile	IV	0.155	0.462	.011	12	view →
SKCM	DFS	Tertile	All	0.642	0.801	.004	12	view →
KIRP	DFS	Quartile	IV	0.033	0.619	.022	12	view →
CESC	DFS	Tertile	All	0.772	0.877	.005	10	view →
UVM	DFS	Median	II,III,IV	0.794	0.446	.038	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

C4orf51–ACC (OS)

Open the ACC breakdown →