C4orf50

Across TCGA pan-cancer cohorts, C4orf50 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C4orf50 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher C4orf50 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C4orf50 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, READ, and SARC are the cancer types where C4orf50 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.121	0.875	<.001	48	view →
READ	OS	Median	All	0.198	0.822	<.001	36	view →
SARC	DFS	Median	All	0.086	0.611	<.001	12	view →
LUSC	DFS	Median	II,III,IV	0.145	0.717	.003	9	view →
COAD	DFS	Median	All	0.421	0.783	.004	6	view →
LUAD	OS	Median	III,IV	0.004	0.662	<.001	6	view →
UCEC	DFS	Median	All	1.000	0.831	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C4orf50–CESC (OS)

Open the CESC breakdown →