C4orf48

Across TCGA patient cohorts, C4orf48 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf48-associated genes across cancer lineages are H3P41, MIR4727, and MIR6504. Each is linked with C4orf48 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf48-to-partner and partner-to-C4orf48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3P41 grouped by C4orf48-low versus C4orf48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf48→partner) and Y-score (partner→C4orf48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H3P41 →	+0.204	+5.081	.005	.008	3	1
UCEC	MIR4727 →	+1.174	+5.551	<.001	.004	3	1
UCEC	MIR6504 →	+0.847	+5.937	<.001	.002	3	1
UCEC	MIR6839 →	+0.510	+5.299	<.001	.006	3	1
UCEC	MIR6133 →	+0.708	+4.982	.001	.009	3	1
UCEC	MIR1266 →	+0.521	+5.771	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

H3P41 by C4orf48 expression — UCEC

Explore this box plot interactively →