C4orf45

Across TCGA patient cohorts, C4orf45 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf45-associated genes across cancer lineages are eIF4E, JNK2, and MEK1. Each is linked with C4orf45 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf45-to-partner and partner-to-C4orf45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by C4orf45-low versus C4orf45-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf45→partner) and Y-score (partner→C4orf45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.202	+3.013	.048	.018	3	1
UCEC	JNK2 →	+0.245	+2.459	.010	.020	3	1
UCEC	MEK1 →	+0.448	+3.321	.011	.009	3	1
UCEC	Notch1 →	+0.169	+2.459	.013	.020	3	1
UCEC	PCNA →	+0.239	+3.584	.022	.002	3	1
UCEC	PDCD4 →	-0.726	-3.449	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4E by C4orf45 expression — UCEC

Explore this box plot interactively →