C4orf45

Across TCGA pan-cancer cohorts, C4orf45 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of C4orf45’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where C4orf45 RNA is repressed in tumor relative to normal tissue. In most cancer types C4orf45 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, UCEC, and LUSC are the cancer types where C4orf45 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C4orf45 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.279	<.001	10	view →
UCEC	All	All	−0.176	<.001	6	view →
LUSC	Male	All	−0.094	<.001	5	view →
LUAD	Female	II,III,IV	−0.135	.016	3	view →
BRCA	All	III,IV	−0.161	<.001	2	view →
LIHC	All	All	+0.029	.045	1	view →
HNSC	Male	All	−0.024	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

C4orf45–THCA

Open the THCA breakdown →