C4orf45

Across TCGA cell cohorts, C4orf45 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,052 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible C4orf45-associated GO terms across cancer lineages are Positive regulation of macroautophagy, Autophagosome organization, and Positive regulation of ubiquitin-dependent protein catabolic process. Each is linked with C4orf45 in more than 5 cancer types. Because this analysis shows association rather than direction, both C4orf45-to-partner and partner-to-C4orf45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of macroautophagy grouped by C4orf45-low versus C4orf45-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf45→partner) and Y-score (partner→C4orf45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of macroautophagy →	+0.043	+0.021	.001	.006	3	6
BLOOD_Lymphoma	Autophagosome organization →	+0.031	+0.051	.001	.007	3	5
PANCREAS	Positive regulation of ubiquitin-dependent protein catabolic process →	+0.041	+0.023	.002	<.001	3	4
SKIN	AMP biosynthetic process →	-0.082	-0.031	.006	.005	2	5
PANCREAS	Positive regulation of autophagy →	+0.050	+0.021	<.001	<.001	3	4
PANCREAS	Regulation of macroautophagy →	+0.041	+0.019	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,052 associations by consensus.

Positive regulation of macroautophagy by C4orf45 expression — PANCREAS

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