C4orf19

Across TCGA patient cohorts, C4orf19 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf19-associated genes across cancer lineages are p62 Lck ligand, Caspase-7-cleavedD198, and Myosin-IIa. Each is linked with C4orf19 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf19-to-partner and partner-to-C4orf19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by C4orf19-low versus C4orf19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf19→partner) and Y-score (partner→C4orf19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.496	+2.817	.005	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+1.084	+3.169	<.001	.020	3	1
UCEC	Myosin-IIa →	+0.256	+2.818	.011	.035	2	1
UCEC	ERK2 →	+0.333	+3.169	.001	.020	1	1
UCEC	MEK1 →	+0.581	+3.169	.003	.020	1	1
UCEC	TFRC →	+0.737	+3.169	.011	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by C4orf19 expression — UCEC

Explore this box plot interactively →