C4orf19

Across TCGA pan-cancer cohorts, C4orf19 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C4orf19’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where C4orf19 RNA is repressed in tumor relative to normal tissue. In most cancer types C4orf19 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where C4orf19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C4orf19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.131	<.001	12	view →
KIRC	Female	II,III,IV	−1.123	<.001	11	view →
HNSC	All	II,III,IV	−1.325	<.001	9	view →
THCA	Male	II,III,IV	−1.035	<.001	9	view →
LUAD	All	All	−0.664	<.001	8	view →
READ	Male	All	−2.246	<.001	7	view →
BRCA	Female	All	−0.627	<.001	6	view →
LUSC	All	II,III,IV	−1.426	<.001	4	view →
CHOL	All	II,III,IV	−1.030	.007	4	view →
PRAD	All	All	−0.926	<.001	2	view →
LIHC	Male	II,III,IV	−0.837	.017	2	view →
KIRP	All	All	−0.432	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C4orf19–COAD

Open the COAD breakdown →