C4orf17

Across TCGA patient cohorts, C4orf17 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf17-associated genes across cancer lineages are Fibronectin, FoxM1, and HER3. Each is linked with C4orf17 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf17-to-partner and partner-to-C4orf17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by C4orf17-low versus C4orf17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf17→partner) and Y-score (partner→C4orf17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.312	-2.446	.016	.018	3	1
UCEC	FoxM1 →	+0.287	+2.009	.004	.017	3	1
UCEC	HER3 →	+0.228	+1.598	.034	.022	3	1
UCEC	ACVRL1 →	-0.167	-2.095	.001	.017	3	1
UCEC	JNK2 →	+0.334	+2.710	<.001	.003	3	1
UCEC	Ku80 →	+0.227	+2.469	.014	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Fibronectin by C4orf17 expression — UCEC

Explore this box plot interactively →