C4BPB

Across TCGA patient cohorts, C4BPB protein abundance is significantly associated with the RNA expression of many other genes, with 16,800 significant associations in total. GBM shows the largest number of these associations.

The most reproducible C4BPB-associated genes across cancer lineages are IL6, SERPINE1, and SLC2A3. Each is linked with C4BPB in more than 9 cancer types. Because this analysis shows association rather than direction, both C4BPB-to-partner and partner-to-C4BPB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C4BPB versus IL6 in GBM, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4BPB→partner) and Y-score (partner→C4BPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL6 →	+2.050	+1.055	<.001	<.001	3	10
OV	SERPINE1 →	+1.912	+0.703	<.001	<.001	3	9
COAD	SLC2A3 →	+1.311	+1.082	<.001	<.001	3	9
CCRCC	MMP19 →	+1.254	+0.606	<.001	<.001	3	8
GBM	TREM1 →	+1.236	+0.642	<.001	<.001	3	8
CCRCC	ADAMTS4 →	+0.862	+0.584	.005	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,800 associations by consensus.

C4BPB vs IL6 — GBM

Explore this scatter interactively →