C4BPB

Across TCGA pan-cancer cohorts, C4BPB RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated C4BPB data layer compared with 5 for mutation status and 9 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher C4BPB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C4BPB expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

LUSC, SCLC, and SKCM are the cancer types where C4BPB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Quartile	II,III,IV	0.262	0.515	.002	74	view →
SCLC	OS	Tertile	All	0.472	0.805	<.001	70	view →
SKCM	OS	Median	All	0.399	0.280	<.001	63	view →
KIRC	DFS	Median	II,III,IV	0.427	0.610	.001	61	view →
UCEC	DFS	Tertile	III,IV	0.755	0.504	.017	40	view →
KIRP	DFS	Tertile	II,III,IV	0.174	1.000	.004	28	view →
UCS	DFS	Tertile	IV	0.419	0.932	.024	24	view →
MESO	DFS	Median	All	0.287	0.437	.008	23	view →
PRAD	DFS	Tertile	All	0.835	0.939	<.001	22	view →
GBM	DFS	Quartile	All	0.203	0.490	.006	15	view →
LIHC	DFS	Tertile	All	0.717	0.473	.004	14	view →
KICH	OS	Median	All	0.767	0.970	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

C4BPB–LUSC (DFS)

Open the LUSC breakdown →