C4BPB

Across TCGA patient cohorts, C4BPB mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4BPB-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and MEK1. Each is linked with C4BPB in more than 1 cancer types. Because this analysis shows association rather than direction, both C4BPB-to-partner and partner-to-C4BPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by C4BPB-low versus C4BPB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4BPB→partner) and Y-score (partner→C4BPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.220	+3.321	.031	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.223	-2.446	.006	.020	3	1
UCEC	MEK1 →	+0.393	+3.321	.026	.010	3	1
UCEC	p62 Lck ligand →	+0.630	+3.584	<.001	.002	3	1
UCEC	Annexin-1 →	+0.946	+3.584	<.001	.002	3	1
UCEC	Rictor_pT1135 →	-0.119	-3.169	.016	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by C4BPB expression — UCEC

Explore this box plot interactively →