C4BPA

Across TCGA pan-cancer cohorts, C4BPA Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C4BPA data layer compared with 23 for mass-spec protein and 9 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher C4BPA Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated C4BPA expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

LGG, ACC, and COAD are the cancer types where C4BPA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.498	0.739	.035	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
COAD	OS	Median	All	0.476	0.808	.013	6	view →
SKCM	DFS	Median	III,IV	0.836	0.220	.022	4	view →
UCEC	DFS	Median	All	0.961	0.830	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C4BPA–LGG (DFS)

Open the LGG breakdown →