C4BPA

Across TCGA pan-cancer cohorts, C4BPA mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated C4BPA data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C4BPA mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C4BPA expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where C4BPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.561	0.880	<.001	72	view →
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	36	view →
LUAD	DFS	Tertile	III,IV	0.337	0.875	.013	23	view →
LSCC	DFS	Median	II,III,IV	0.840	1.000	.007	18	view →
UCEC	OS	Median	All	0.907	1.000	.011	14	view →
PDAC	OS	Quartile	All	0.561	1.000	<.001	14	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.902	.005	10	view →
GBM	DFS	Median	All	0.439	0.218	.023	7	view →
OV	DFS	Median	All	1.000	0.854	.025	4	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

C4BPA–CCRCC (OS)

Open the CCRCC breakdown →