C4BPA

Across TCGA pan-cancer cohorts, C4BPA mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of C4BPA’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where C4BPA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types C4BPA is over-expressed in tumor, although a few such as LSCC and HNSC show the opposite, repressed pattern.

LSCC, HNSC, and COAD are the cancer types where C4BPA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C4BPA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	−1.069	<.001	8	view →
HNSC	Male	II,III,IV	−0.470	<.001	8	view →
COAD	All	All	−0.398	<.001	8	view →
LUAD	Female	II,III,IV	−0.828	<.001	7	view →
PDAC	Female	All	+0.713	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

C4BPA–LSCC

Open the LSCC breakdown →