C4B-AS1

Across TCGA patient cohorts, C4B-AS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,217 significant associations in total. LGG shows the largest number of these associations.

The most reproducible C4B-AS1-associated GO terms across cancer lineages are Leptin-mediated signaling pathway, Vascular associated smooth muscle cell apoptotic process, and Mesenchymal cell differentiation. Each is linked with C4B-AS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both C4B-AS1-to-partner and partner-to-C4B-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Leptin-mediated signaling pathway grouped by C4B-AS1-low versus C4B-AS1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C4B-AS1→partner) and Y-score (partner→C4B-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Leptin-mediated signaling pathway →	+0.063	+0.002	.005	.002	3	2
LGG	Vascular associated smooth muscle cell apoptotic process →	+0.060	+0.004	<.001	.002	3	2
LGG	Mesenchymal cell differentiation →	+0.023	+0.002	<.001	<.001	3	2
LGG	Smooth muscle cell differentiation →	+0.027	+0.003	<.001	<.001	3	2
LGG	Negative regulation of muscle cell differentiation →	+0.040	+0.002	<.001	<.001	3	2
LGG	Intrinsic apoptotic signaling pathway in response to DNA damage →	+0.027	+0.003	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,217 associations by consensus.

Leptin-mediated signaling pathway by C4B-AS1 expression — STAD

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