C4B-AS1

Across TCGA pan-cancer cohorts, C4B-AS1 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated C4B-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher C4B-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C4B-AS1 expression acts as an unfavorable survival marker.

LUAD, KIRC, and BRCA are the cancer types where C4B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.079	0.677	<.001	84	view →
KIRC	DFS	Tertile	IV	0.251	0.647	<.001	36	view →
BRCA	OS	Tertile	III,IV	0.747	0.909	.009	24	view →
UCS	DFS	Tertile	All	0.136	0.523	.034	18	view →
STAD	OS	Tertile	IV	0.001	0.544	<.001	18	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
THCA	DFS	Tertile	IV	0.514	0.935	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C4B-AS1–LUAD (OS)

Open the LUAD breakdown →