C4A-AS1

Across TCGA pan-cancer cohorts, C4A-AS1 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated C4A-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher C4A-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C4A-AS1 expression acts as an unfavorable survival marker, although some lineages such as LIHC show a favorable association.

KIRP, PAAD, and BLCA are the cancer types where C4A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	IV	0.088	0.502	<.001	36	view →
PAAD	OS	Tertile	II,III,IV	0.210	0.556	.007	36	view →
BLCA	DFS	Tertile	All	0.153	0.615	.020	27	view →
CESC	DFS	Tertile	All	0.452	0.744	.029	18	view →
PCPG	DFS	Tertile	All	0.104	0.904	<.001	18	view →
SKCM	DFS	Tertile	III,IV	0.043	0.597	<.001	18	view →
LIHC	OS	Tertile	II,III,IV	0.640	0.353	.007	18	view →
CHOL	DFS	Tertile	All	0.121	0.495	.024	18	view →
GBM	DFS	Tertile	All	0.095	0.250	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

C4A-AS1–KIRP (DFS)

Open the KIRP breakdown →