C3orf85

Across TCGA pan-cancer cohorts, C3orf85 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of C3orf85’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C3orf85 RNA is repressed in tumor relative to normal tissue. In most cancer types C3orf85 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where C3orf85 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C3orf85 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.373	<.001	12	view →
COAD	Female	II,III,IV	−2.047	<.001	11	view →
KIRP	All	III,IV	−1.904	<.001	9	view →
LIHC	Female	II,III,IV	−1.797	<.001	9	view →
KICH	All	II,III,IV	−1.691	<.001	7	view →
CHOL	All	All	−2.188	<.001	5	view →
READ	All	II,III,IV	−1.467	.003	4	view →
LUSC	All	II,III,IV	+0.006	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

C3orf85–KIRC

Open the KIRC breakdown →