C3orf84

Across TCGA patient cohorts, C3orf84 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf84-associated genes across cancer lineages are EGFR_pY1068, MEK1, and PRDX1. Each is linked with C3orf84 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf84-to-partner and partner-to-C3orf84 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by C3orf84-low versus C3orf84-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf84→partner) and Y-score (partner→C3orf84) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.239	-2.459	.049	.020	3	1
UCEC	MEK1 →	+0.496	+3.584	.004	.002	3	1
UCEC	PRDX1 →	+0.252	+3.169	.011	.019	3	1
UCEC	Rab25 →	-0.359	-3.169	.025	.019	3	1
UCEC	TIGAR →	+0.216	+3.611	.003	.001	3	1
UCEC	TSC1 →	-0.249	-3.584	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by C3orf84 expression — UCEC

Explore this box plot interactively →