Across TCGA patient cohorts, C3orf56 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf56-associated genes across cancer lineages are N-Cadherin, Cyclin-E2, and Ku80. Each is linked with C3orf56 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf56-to-partner and partner-to-C3orf56 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf56→partner) and Y-score (partner→C3orf56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Cadherin →	+0.209	+2.321	.049	.035	3	2
UCEC	Cyclin-E2 →	+0.253	+3.459	.002	.005	3	2
UCEC	Ku80 →	+0.242	+3.009	.042	.019	3	1
UCEC	P-Cadherin →	-0.149	-2.308	.040	.036	3	1
UCEC	PCNA →	+0.368	+3.169	<.001	.019	3	1
UCEC	RAD51 →	+0.139	+2.321	.047	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

C3orf56 survival (RNA) · tumor vs normal (RNA) · all C3orf56 data types