Across TCGA pan-cancer cohorts, C3orf56 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of C3orf56’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where C3orf56 RNA is repressed in tumor relative to normal tissue. In most cancer types C3orf56 is over-expressed in tumor, although a few such as PAAD and BRCA show the opposite, repressed pattern.

PAAD, BRCA, and LUSC are the cancer types where C3orf56 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C3orf56 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PAAD	Female	All	−0.080	.015	4	view →
BRCA	All	II,III,IV	−0.007	.047	2	view →
LUSC	Male	All	−0.009	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: C3orf56 RNA expression & survival · all C3orf56 data types