C3orf49

Across TCGA cell cohorts, C3orf49 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,126 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible C3orf49-associated GO terms across cancer lineages are Regulation of double-strand break repair, Positive regulation of DNA metabolic process, and Microtubule nucleation. Each is linked with C3orf49 in more than 8 cancer types. Because this analysis shows association rather than direction, both C3orf49-to-partner and partner-to-C3orf49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair grouped by C3orf49-low versus C3orf49-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf49→partner) and Y-score (partner→C3orf49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.056	+0.034	.006	.006	3	9
BLOOD_Lymphoma	Positive regulation of DNA metabolic process →	+0.049	+0.125	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Microtubule nucleation →	+0.097	+0.060	.001	<.001	3	8
BLOOD_Lymphoma	Regulation of DNA-templated DNA replication →	+0.063	+0.123	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.060	+0.035	.005	.003	3	8
BLOOD_Leukemia	Microtubule polymerization →	+0.101	+0.130	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,126 associations by consensus.

Regulation of double-strand break repair by C3orf49 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →