C3orf49

Across TCGA pan-cancer cohorts, C3orf49 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of C3orf49’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where C3orf49 RNA is repressed in tumor relative to normal tissue. In most cancer types C3orf49 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where C3orf49 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C3orf49 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.375	<.001	11	view →
KIRC	Male	All	−0.196	<.001	11	view →
KICH	Female	All	−0.345	<.001	7	view →
LUAD	Female	II,III,IV	−0.345	<.001	7	view →
LUSC	Female	All	−0.405	<.001	6	view →
KIRP	Male	All	−0.238	<.001	6	view →
UCEC	All	All	−0.508	<.001	4	view →
BRCA	All	All	−0.269	<.001	4	view →
HNSC	All	All	−0.108	.001	4	view →
BLCA	Male	III,IV	−0.357	.045	1	view →
LIHC	Male	All	+0.065	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

C3orf49–THCA

Open the THCA breakdown →