C3orf49

Across TCGA cell cohorts, C3orf49 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C3orf49-associated genes across cancer lineages are MAGEB4, CSN2, and STRA8. Each is linked with C3orf49 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf49-to-partner and partner-to-C3orf49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by C3orf49-low versus C3orf49-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf49→partner) and Y-score (partner→C3orf49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CSN2 →	+0.024	+4.684	.003	.002	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	PPDPFL →	+0.061	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	KRTAP5-11 →	+0.056	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MAGEB4 by C3orf49 expression — LARGE_INTESTINE

Explore this box plot interactively →