C3orf22

Across TCGA patient cohorts, C3orf22 mutation is significantly associated with the RNA expression of many other genes, with 493 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf22-associated genes across cancer lineages are MIR4666B, RNU6-818P, and RNU11-5P. Each is linked with C3orf22 in more than 2 cancer types. Because this analysis shows association rather than direction, both C3orf22-to-partner and partner-to-C3orf22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4666B grouped by C3orf22-low versus C3orf22-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf22→partner) and Y-score (partner→C3orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4666B →	+0.690	+7.731	<.001	.009	3	3
BRCA	RNU6-818P →	+0.572	+7.731	<.001	.009	3	2
BRCA	RNU11-5P →	+0.186	+7.731	<.001	.009	3	2
UCEC	MIR7702 →	+0.229	+4.253	<.001	.004	3	2
BRCA	MIR8052 →	+0.481	+7.731	<.001	.009	3	1
BRCA	DUX4L8 →	+0.034	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 493 associations by consensus.

MIR4666B by C3orf22 expression — BRCA

Explore this box plot interactively →