C3orf22

Across TCGA pan-cancer cohorts, C3orf22 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C3orf22 data layer compared with 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C3orf22 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C3orf22 expression acts as an unfavorable survival marker, although some lineages such as BLCA and LGG show a favorable association.

UCEC, BLCA, and PCPG are the cancer types where C3orf22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.545	0.755	<.001	108	view →
BLCA	OS	Tertile	II,III,IV	0.733	0.567	.009	44	view →
PCPG	DFS	Median	All	0.563	0.896	<.001	42	view →
LUAD	DFS	Quartile	IV	0.342	0.939	.004	32	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	24	view →
LGG	OS	Tertile	All	0.955	0.831	<.001	23	view →
SKCM	DFS	Tertile	II,III,IV	0.785	0.656	.009	22	view →
KICH	DFS	Quartile	III,IV	0.285	1.000	.015	18	view →
LUSC	DFS	Quartile	III,IV	0.304	0.591	.005	17	view →
ACC	DFS	Tertile	IV	0.564	0.057	.024	12	view →
UVM	OS	Tertile	All	1.000	0.626	.037	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C3orf22–UCEC (DFS)

Open the UCEC breakdown →