C3orf22

Across TCGA patient cohorts, C3orf22 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf22-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and MSH2. Each is linked with C3orf22 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf22-to-partner and partner-to-C3orf22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by C3orf22-low versus C3orf22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf22→partner) and Y-score (partner→C3orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.208	-3.169	<.001	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.140	-3.312	.025	.010	3	1
UCEC	MSH2 →	-0.338	-3.160	.003	.019	3	1
UCEC	p62 Lck ligand →	+0.527	+3.009	.001	.019	3	1
UCEC	PKC-delta_pS664 →	-0.136	-2.321	.024	.035	3	1
UCEC	Rab25 →	-0.520	-3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

A-Raf_pS299 by C3orf22 expression — UCEC

Explore this box plot interactively →