C3orf22

Across TCGA cell cohorts, C3orf22 RNA expression is significantly associated with the go_rna of many other GO terms, with 903 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C3orf22-associated GO terms across cancer lineages are Regulation of neuron differentiation, Calcium-independent cell-matrix adhesion, and Response to silicon dioxide. Each is linked with C3orf22 in more than 3 cancer types. Because this analysis shows association rather than direction, both C3orf22-to-partner and partner-to-C3orf22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of neuron differentiation grouped by C3orf22-low versus C3orf22-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf22→partner) and Y-score (partner→C3orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of neuron differentiation →	-0.037	-0.006	.007	.009	3	4
LUNG_NSCLC_LUAD	Calcium-independent cell-matrix adhesion →	+0.098	+0.020	.006	.006	3	4
LUNG_NSCLC_LUAD	Response to silicon dioxide →	+0.127	+0.029	<.001	<.001	3	4
PANCREAS	Positive regulation of oxidative phosphorylation →	+0.084	+0.019	.006	.008	3	4
PANCREAS	Plasmacytoid dendritic cell activation →	-0.157	-0.020	<.001	.004	3	4
BLOOD_Leukemia	Regulation of heart rate →	-0.057	-0.036	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 903 associations by consensus.

Regulation of neuron differentiation by C3orf22 expression — CNS

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