C3orf22

Across TCGA cell cohorts, C3orf22 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible C3orf22-associated genes across cancer lineages are KCTD8, MMP27, and CCL19. Each is linked with C3orf22 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf22-to-partner and partner-to-C3orf22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD8 grouped by C3orf22-low versus C3orf22-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf22→partner) and Y-score (partner→C3orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCTD8 →	+0.149	+4.510	.009	.001	3	1
LUNG_NSCLC_LUAD	MMP27 →	+0.029	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	CCL19 →	+0.080	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	ASCL4 →	+0.006	+5.228	.005	.005	3	1
LUNG_NSCLC_LUAD	KRTAP5-11 →	+0.069	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KCTD8 by C3orf22 expression — LARGE_INTESTINE

Explore this box plot interactively →