C2orf83

Across TCGA pan-cancer cohorts, C2orf83 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C2orf83 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher C2orf83 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C2orf83 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BLCA, BRCA, and SKCM are the cancer types where C2orf83 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.051	0.684	<.001	24	view →
BRCA	DFS	Median	All	0.130	0.527	<.001	12	view →
SKCM	OS	Median	All	1.000	0.777	.032	4	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C2orf83–BLCA (OS)

Open the BLCA breakdown →