C2orf81

Across TCGA cell cohorts, C2orf81 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C2orf81-associated genes across cancer lineages are TBC1D3, CBY1, and C6orf118. Each is linked with C2orf81 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf81-to-partner and partner-to-C2orf81 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by C2orf81-low versus C2orf81-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf81→partner) and Y-score (partner→C2orf81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D3 →	+0.066	+3.009	<.001	.001	3	2
LARGE_INTESTINE	CBY1 →	+0.953	+3.160	<.001	.006	3	1
LARGE_INTESTINE	C6orf118 →	+0.099	+2.793	<.001	.002	3	1
LARGE_INTESTINE	RPS10 →	+0.541	+3.067	<.001	.009	3	1
LARGE_INTESTINE	RSPH10B →	+0.214	+3.215	.009	.009	3	1
LARGE_INTESTINE	SSMEM1 →	+0.020	+2.707	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TBC1D3 by C2orf81 expression — LARGE_INTESTINE

Explore this box plot interactively →