Across TCGA patient cohorts, C2orf78 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2orf78-associated genes across cancer lineages are Cyclin-B1, A-Raf_pS299, and PCNA. Each is linked with C2orf78 in more than 3 cancer types. Because this analysis shows association rather than direction, both C2orf78-to-partner and partner-to-C2orf78 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf78→partner) and Y-score (partner→C2orf78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.849	+3.000	.001	.036	3	4
UCEC	A-Raf_pS299 →	-0.082	-1.807	.036	.025	3	2
UCEC	PCNA →	+0.140	+1.584	.048	.034	3	2
UCEC	STAT3_pY705 →	-0.325	-1.584	<.001	.015	3	2
UCEC	Tuberin →	+0.294	+1.857	<.001	.004	3	2
UCEC	VHL →	-0.648	-1.584	.003	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

C2orf78 survival (RNA) · tumor vs normal (RNA) · all C2orf78 data types