Across TCGA pan-cancer cohorts, C2orf78 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of C2orf78’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where C2orf78 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C2orf78 is over-expressed in tumor.

KIRP, LUAD, and LUSC are the cancer types where C2orf78 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2orf78 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	+0.039	.002	6	view →
LUAD	All	All	+0.008	.027	4	view →
LUSC	All	II,III,IV	+0.010	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: C2orf78 RNA expression & survival · all C2orf78 data types