Across TCGA patient cohorts, C2orf66 mutation is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2orf66-associated genes across cancer lineages are RNU6-607P, RN7SL478P, and MIR5787. Each is linked with C2orf66 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf66-to-partner and partner-to-C2orf66 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf66→partner) and Y-score (partner→C2orf66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-607P →	+0.374	+5.097	<.001	.008	3	2
UCEC	RN7SL478P →	+0.555	+3.676	<.001	.001	3	1
SKCM	MIR5787 →	+0.539	+5.513	<.001	.004	3	1
UCEC	CYP2C19 →	+0.042	+3.041	.008	.008	3	1
UCEC	CRYGA →	+0.295	+3.452	.007	.003	3	1
UCEC	TRIM60 →	+0.087	+3.303	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Exploration

C2orf66 survival (RNA) · tumor vs normal (RNA) · all C2orf66 data types