C2orf50

Across TCGA patient cohorts, C2orf50 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2orf50-associated genes across cancer lineages are RAB28P2, PHBP17, and MIR548O2. Each is linked with C2orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf50-to-partner and partner-to-C2orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB28P2 grouped by C2orf50-low versus C2orf50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf50→partner) and Y-score (partner→C2orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAB28P2 →	+0.141	+4.722	<.001	.004	3	2
CESC	PHBP17 →	+0.096	+6.144	<.001	.001	3	1
CESC	MIR548O2 →	+0.315	+5.669	<.001	.003	3	1
UCEC	NUTF2P8 →	+0.180	+3.982	<.001	.003	3	1
UCEC	RN7SL248P →	+0.139	+4.722	<.001	.004	3	1
UCEC	RNA5SP411 →	+1.985	+3.393	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

RAB28P2 by C2orf50 expression — UCEC

Explore this box plot interactively →