C2orf49

Across TCGA pan-cancer cohorts, C2orf49 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C2orf49 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C2orf49 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C2orf49 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where C2orf49 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.766	0.951	.005	19	view →
LSCC	DFS	Tertile	All	0.985	0.863	.019	13	view →
LUAD	DFS	Median	II,III,IV	0.469	0.712	.029	4	view →
CCRCC	OS	Quartile	All	0.927	0.772	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C2orf49–HNSC (OS)

Open the HNSC breakdown →