Across TCGA patient cohorts, C2orf16 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2orf16-associated genes across cancer lineages are p38-MAPK, P-Cadherin, and 4E-BP1_pT37_T46. Each is linked with C2orf16 in more than 2 cancer types. Because this analysis shows association rather than direction, both C2orf16-to-partner and partner-to-C2orf16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf16→partner) and Y-score (partner→C2orf16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	p38-MAPK →	-0.137	-2.321	.007	.031	3	3
LUSC	P-Cadherin →	+0.252	+3.321	.002	.009	3	3
UCEC	4E-BP1_pT37_T46 →	-0.291	-1.571	.004	.007	3	3
UCEC	C-Raf →	+0.123	+1.263	.001	.016	3	3
LUSC	PAI-1 →	+0.606	+1.494	.012	.035	3	2
COAD	FASN →	+0.567	+2.593	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Exploration

C2orf16 survival (RNA) · tumor vs normal (RNA) · all C2orf16 data types