Across TCGA pan-cancer cohorts, C2orf16 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C2orf16’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where C2orf16 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C2orf16 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.
LUAD, HNSC, and LIHC are the cancer types where C2orf16 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2orf16 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.