Across TCGA cell cohorts, C2orf16 mutation is significantly associated with the RNA expression of many other genes, with 1,594 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C2orf16-associated genes across cancer lineages are METTL4, USP34, and PLEKHA3. Each is linked with C2orf16 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf16-to-partner and partner-to-C2orf16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf16→partner) and Y-score (partner→C2orf16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	METTL4 →	+0.669	+3.389	<.001	.001	3	2
LARGE_INTESTINE	USP34 →	+0.488	+2.459	<.001	.006	3	2
BLOOD_Leukemia	PLEKHA3 →	+0.745	+3.263	<.001	.005	3	2
BLOOD_Leukemia	SFPQ →	+0.423	+3.411	.006	.003	3	2
LARGE_INTESTINE	GPR89A →	+0.428	+2.244	<.001	.003	3	2
BLOOD_Leukemia	CCDC77 →	+0.638	+3.351	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,594 associations by consensus.

Exploration

C2orf16 survival (RNA) · tumor vs normal (RNA) · all C2orf16 data types