Across TCGA patient cohorts, C2CD4D mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2CD4D-associated genes across cancer lineages are MAGED4, KRTAP20-3, and LYZL1. Each is linked with C2CD4D in more than 1 cancer types. Because this analysis shows association rather than direction, both C2CD4D-to-partner and partner-to-C2CD4D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2CD4D→partner) and Y-score (partner→C2CD4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAGED4 →	+0.031	+3.194	.006	.003	3	2
UCEC	KRTAP20-3 →	+0.136	+5.475	<.001	.001	3	2
CESC	LYZL1 →	+0.053	+5.418	<.001	.005	3	1
CESC	RPL9P13 →	+0.141	+5.010	<.001	.009	3	1
CESC	DDX6P1 →	+0.041	+5.418	<.001	.005	3	1
COAD	RNA5SP442 →	+0.654	+5.893	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

C2CD4D survival (RNA) · tumor vs normal (RNA) · all C2CD4D data types