Across TCGA pan-cancer cohorts, C2CD4D RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C2CD4D data layer compared with 4 for mutation status.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C2CD4D RNA is associated with better overall survival. In most high-consensus cancer types, elevated C2CD4D expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.
HNSC, SCLC, and KIRP are the cancer types where C2CD4D RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.