Across TCGA pan-cancer cohorts, C22orf46 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated C22orf46 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C22orf46 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C22orf46 expression acts as an unfavorable survival marker.

UCEC are the cancer types where C22orf46 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: C22orf46 tumor-vs-normal RNA expression · all C22orf46 data types