Across TCGA pan-cancer cohorts, C22orf46 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of C22orf46’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C22orf46 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C22orf46 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.
HNSC, LIHC, and THCA are the cancer types where C22orf46 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C22orf46 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.