Across TCGA patient cohorts, C22orf46 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C22orf46-associated genes across cancer lineages are PCNA, Bad_pS112, and 4E-BP1. Each is linked with C22orf46 in more than 1 cancer types. Because this analysis shows association rather than direction, both C22orf46-to-partner and partner-to-C22orf46 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf46→partner) and Y-score (partner→C22orf46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.261	+2.000	.004	.030	3	2
UCEC	Bad_pS112 →	-0.274	-2.222	<.001	.011	3	2
COAD	4E-BP1 →	+0.297	+3.178	.006	.010	3	2
UCEC	EGFR_pY1068 →	-0.305	-2.906	.004	.001	3	1
UCEC	A-Raf_pS299 →	-0.155	-3.459	.002	.005	3	1
UCEC	ERK2 →	+0.180	+1.700	.027	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

C22orf46 survival (RNA) · tumor vs normal (RNA) · all C22orf46 data types