Across TCGA cell cohorts, C22orf46 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,162 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C22orf46-associated GO terms across cancer lineages are Positive regulation of T-helper 17 cell lineage commitment, Negative regulation of chromosome condensation, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with C22orf46 in more than 14 cancer types. Because this analysis shows association rather than direction, both C22orf46-to-partner and partner-to-C22orf46 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf46→partner) and Y-score (partner→C22orf46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of T-helper 17 cell lineage commitment →	+0.206	+1.183	<.001	<.001	3	15
PANCREAS	Negative regulation of chromosome condensation →	+0.183	+0.998	<.001	<.001	3	14
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.158	+1.221	.005	.003	3	13
PANCREAS	miRNA processing →	+0.080	+0.775	.007	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Microtubule polymerization →	+0.108	+1.438	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA export from nucleus →	+0.112	+1.187	<.001	.006	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,162 associations by consensus.

Exploration

C22orf46 survival (RNA) · tumor vs normal (RNA) · all C22orf46 data types