C22orf39

Across TCGA patient cohorts, C22orf39 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C22orf39-associated genes across cancer lineages are RN7SKP181, LINC02563, and TRIM49. Each is linked with C22orf39 in more than 1 cancer types. Because this analysis shows association rather than direction, both C22orf39-to-partner and partner-to-C22orf39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by C22orf39-low versus C22orf39-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf39→partner) and Y-score (partner→C22orf39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP181 →	+0.258	+4.133	<.001	<.001	3	2
UCEC	LINC02563 →	+0.212	+3.683	<.001	.003	3	1
UCEC	TRIM49 →	+0.345	+2.798	.001	.008	3	1
COAD	VENTXP7 →	+0.224	+5.283	<.001	.006	3	1
COAD	RN7SL835P →	+0.524	+5.283	<.001	.006	3	1
UCEC	AQP7P2 →	+0.358	+2.747	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

RN7SKP181 by C22orf39 expression — UCEC

Explore this box plot interactively →