C22orf24

Across TCGA patient cohorts, C22orf24 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C22orf24-associated genes across cancer lineages are NPLP1, MIR1229, and MEMO1P3. Each is linked with C22orf24 in more than 1 cancer types. Because this analysis shows association rather than direction, both C22orf24-to-partner and partner-to-C22orf24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPLP1 grouped by C22orf24-low versus C22orf24-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf24→partner) and Y-score (partner→C22orf24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NPLP1 →	+0.207	+5.080	<.001	.008	3	2
BLCA	MIR1229 →	+0.429	+5.106	<.001	.008	3	1
BLCA	MEMO1P3 →	+0.114	+4.973	.004	.009	3	1
UCEC	NTSR2 →	+0.587	+3.431	<.001	.009	3	1
UCEC	MIR425 →	+0.682	+3.329	<.001	.004	3	1
UCEC	RNU1-17P →	+0.524	+4.350	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

NPLP1 by C22orf24 expression — COAD

Explore this box plot interactively →