C22orf24

Across TCGA pan-cancer cohorts, C22orf24 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C22orf24 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher C22orf24 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated C22orf24 expression acts as an unfavorable survival marker, although some lineages such as UCS and THYM show a favorable association.

UCS, ACC, and THYM are the cancer types where C22orf24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.485	0.127	<.001	100	view →
ACC	DFS	Tertile	All	0.206	0.678	<.001	66	view →
THYM	OS	Tertile	II,III,IV	1.000	0.512	.002	32	view →
BLCA	DFS	Tertile	II,III,IV	0.227	0.393	.009	32	view →
READ	OS	Median	II,III,IV	0.793	0.422	.003	21	view →
BRCA	DFS	Tertile	IV	0.913	0.424	.012	14	view →
SCLC	DFS	Median	II,III,IV	0.727	0.458	.012	13	view →
KIRP	DFS	Tertile	III,IV	0.857	0.384	.040	12	view →
KICH	OS	Median	II,III,IV	1.000	0.880	.004	10	view →
SKCM	DFS	Median	IV	0.633	0.073	.011	10	view →
LUSC	OS	Median	IV	0.057	0.786	.008	9	view →
COAD	OS	Median	All	0.905	0.830	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C22orf24–UCS (DFS)

Open the UCS breakdown →